GMDS and melanoma: For example, a mutation in GMDS was shown to induce the proliferation of colon cancer cells [16], SDF2L1 expression was found to be upregulated when nasopharyngeal carcinoma cell growth was promoted in vitro [17], KLHL17 was shown to be associated with prostate cancer [18], ITGB5 was considered to serve as a prognostic biomarker for poor prognosis in gastric cancer [19], and KLHL41 expression was found to be significantly enhanced in melanoma [20].