Feng et al. found that Nrf2 could activate SLC7A11 to inhibit ferroptosis, and reduce the radiosensitivity of esophageal squamous cell carcinoma [74, 81]; Ruiran Wei et al. found that the activated Nrf2-HO-1 pathway could increase the level of Fe2+ and induce ferroptosis in colorectal cancer cells [82]. The gene discussed is NFE2L2; the disease is colorectal cancer.