NFE2L2 and esophageal squamous cell carcinoma: Feng et al. found that Nrf2 could activate SLC7A11 to inhibit ferroptosis, and reduce the radiosensitivity of esophageal squamous cell carcinoma [74, 81]; Ruiran Wei et al. found that the activated Nrf2-HO-1 pathway could increase the level of Fe2+ and induce ferroptosis in colorectal cancer cells [82].