To clarify the role of Rab37 in autophagy and TIMP1 secretion, Rab37 gene expression was silenced by lentiviral shRNA, and the levels of Rab37, LC3-II in lung cancer H460 cells, as well as the secretion of TIMP1 in condition media were decreased (Fig. 2a). The gene discussed is TIMP1; the disease is lung cancer.