Notably, nine of the 70 predicted miR-24-3p target genes (PLEKHG6, PRSS8, GBA2, STRADB, HMOX1, LPCAT3, BCL2L11, MPI, and GMFB) are significantly downregulated (DESeq2; average expression > 1000 normalized counts, > 1.5 × fold change, p-adj < 0.05) in TCGA colon tumor relative to non-tumor tissue (Fig. 7B, shown by triangles), including HMOX1 and PRSS8, which exhibit the highest upregulation among the nine (Fig. 7D). Here, PRSS8 is linked to colonic neoplasm.