The diagnostic values (including sensitivity, specificity, negative predictive value, positive predictive value, positive likelihood ratio, negative likelihood ratio, and accuracy) of CD4+IFN-γ+CD38+/CD4+IFN-γ+, CD4+IFN-γ+CD27−/CD4+IFN-γ+, CD4+IFN-γ+CD38+CD27−/CD4+IFN-γ+, CD4+IFN-γ+CD38+CD27−/CD4+, CD4+IFN-γ+CD38+/CD4+, CD4+IFN-γ+CD27−/CD4+ for the diagnosis and differential diagnosis of TB were evaluated (Table 2). This evidence concerns the gene CD38 and tuberculosis.