Interestingly, previous studies have found relevant associations between the gene and related phenotypes: a study of the RNA blood transcriptome of patients with Alzheimer’s disease (AD), a disease which involves severe memory impairments, found that the largest expression fold change among differentially expressed genes across AD cases and controls was with TGM3 [79]. The gene discussed is TGM3; the disease is early-onset autosomal dominant Alzheimer disease.