Meanwhile, ectopic expression of P65 also rescued S phase blockage and expression of cell cycle-related genes including CDK2, Cyclin D1 and Cyclin E1, in addition to NF-κB target genes including IL-1β, IL-6 and TNFα in lung cancer cells overexpressing ZNF24 (Fig. 4O, P and Additional file 4: Figure S5D–G). Here, CDK2 is linked to lung cancer.