The analysis of putative target genes of castration-resistant prostate cancer indicated that specific downregulation of miR-34b-5p after the combination therapy of docetaxel and Fuzheng Yiliu decoction might hinder the PI3K–Akt signaling pathway to suppress cell survival, growth, and proliferation, and facilitate apoptosis resulting in enhanced anticancer effects (Fig. 1C) [34]. This evidence concerns the gene AKT1 and prostate cancer.