Consistently, after modulate the expression of c-Rel, not only group 1 mir-133 family, but also the majority members of mir-379-369 cluster were affected as well, while p65 and p50 increases the risk of cervical cancer incidence or development in early or late stages of HPV16 infection by affecting only miR-133a-5p or mir-379-369 cluster corresponding respectively. The gene discussed is NFKB1; the disease is cervical cancer.