We also found that serum IL-18 in remission was significantly higher in the FMF patients with MEFV exon 10 mutation than in those without mutation [7], and furthermore, our recent study showed that the coexistence of MEFV exon 2 variants boosted serum IL-18 levels in remission among patients with FMF that had a heterozygous MEFV exon 10 mutation [8]. This evidence concerns the gene IL18 and familial Mediterranean fever.