Considering nucleotide-binding domain leucine-rich repeat (NLR) proteins 3 (NLRP3), NLRP3 inflammasome activation and IL-1β/IL-18 secretion have recently emerged as a central mechanism in the pathogenesis of diseases associated with NLRP3 activation by danger signals like gout, pseudogout, Alzheimer’s disease, or type 2 diabetes [18]. The gene discussed is IL18; the disease is gout.