Furthermore, these advanced procedures are not only restricted to immunohistochemical staining of specific markers, but molecular studies have also become a major player in differentiating some aggressive subtypes of lymphomas, such as diffuse large B-cell lymphoma/high grade large B-cell lymphoma with MYC and BCL2 rearrangements, from DLBCL, NOS. The gene discussed is BCL2; the disease is lymphoma.