On the other hand, CAND1 (Cullin-associated neural-precursor-cell-expressed developmentally down-regulated 8 (NEDD8) dissociated protein 1 (CAND1)), a regulator of cullin-RING (a fascinating novel gene) ubiquitin ligases (CRLs), is implicated in the development of cancer resistance [32, 33]. This evidence concerns the gene CACUL1 and cancer.