Ultimately, 2 miRNAs (namely, miR-132-3p and miR-576-5p) and 4 mRNAs (namely, CAND1, ZDHHC23, AHR, and MTMR4) were obtained followed bioinformatics analyses, and possessed the potential to serve as prognostic biomarkers for radiosensitivity in esophageal cancer patients. The gene discussed is MTMR4; the disease is esophageal cancer.