Ultimately, 2 miRNAs (namely, miR-132-3p and miR-576-5p) and 4 mRNAs (namely, CAND1, ZDHHC23, AHR, and MTMR4) were obtained followed bioinformatics analyses, and possessed the potential to serve as prognostic biomarkers for radiosensitivity in esophageal cancer patients. Here, ZDHHC23 is linked to esophageal cancer.