Furthermore, we uncovered that the prognostic risk model based on 2 miRNAs (miR-132-3p and miR-576-5p) and 4 mRNAs (CAND1, ZDHHC23, AHR, and MTMR4) could accurately and effectively predict the prognosis of patients with esophageal cancer. This evidence concerns the gene CAND1 and esophageal cancer.