Then, 3 HCC samples with high expression of APEX1, ME1, S100A10 and ACACA and low expression of ADH1C and CYP2C9 were taken as the high risk score group, and 6 HCC samples with low expression of APEX1, ME1, S100A10 and ACACA and high expression of ADH1C and CYP2C9 were selected as the low risk score group. This evidence concerns the gene ADH1C and hepatocellular carcinoma.