According to the follow-up and gene expression data of TCGA, high expression of APEX1, ME1, S100A10 and ACACA was closely associated with poor prognosis, while high expression of ADH1C, CYP2C9 improved the prognosis of HCC patients (P < 0.05, Fig. 6C). The gene discussed is ME1; the disease is hepatocellular carcinoma.