According to the follow-up and gene expression data of TCGA, high expression of APEX1, ME1, S100A10 and ACACA was closely associated with poor prognosis, while high expression of ADH1C, CYP2C9 improved the prognosis of HCC patients (P < 0.05, Fig. 6C). Here, S100A10 is linked to hepatocellular carcinoma.