However, c-AID signatures were less abundant than other tumor-specific major signatures, for example the ultraviolet (UV) exposure related signatures (SBS7a and SBS7b) in skin melanoma had a frequency of 65.0% (26.0 + 39.0%) versus 7.9% of c-AID; the tobacco smoking signature (SBS4) in Lung adenocarcinoma with a 50.0% frequency versus 4.2% of c-AID; and the temozolomide-related signature (SBS11) in glioblastoma (GBM) with 25.2% versus 7.7% of c-AID (Supplementary Fig. 1). The gene discussed is SGO1; the disease is neoplasm.