AICDA and neoplasm: We next sought to compare the cumulative distribution of the AID/APOBEC ICNs in terms of population hotspot mutations recurrency finding that AID produces ICNs at hotspots with greater positive selection (FC = 1.59; P = 3e-41, two-sample Z-test for equal proportion, Fig. 4a) which could give rise to higher possibilities of immune recognition and improved tumor control.