Summing up the findings that globally AICDA expression and c-AID mutations were not correlated in the TCGA nor in ICGC datasets plus that mostly only the immunoglobulin genes’ expression was correlated with c-AID mutations in hematological cancers, it is tempting to speculate that the genotoxic effect of AID might be due to short-term activation of AICDA, which have been seen in APOBEC42. The gene discussed is AICDA; the disease is hematopoietic and lymphoid cell neoplasm.