Since recent studies have unraveled that composite mutations, pair of driver–driver, driver–passenger, or passenger–passenger mutations on the same gene, can synergize the functional impact compared to their single-mutated contra part, we analyzed the contribution of c-AID mutations within this phenomenon by analyzing 31,353 samples comprising 41 tumor types from the MSKCC cohort (Fig. 5). The gene discussed is AICDA; the disease is neoplasm.