The AID mutations were more frequently negatively correlated with the TMB of cancers from TCGA (i.e., in adenoid cystic carcinoma (ACC), kidney renal papillary cell carcinoma (KIRP), kidney renal clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), ovarian cancer (OV), and THCA; Supplementary Fig. 10). Here, AICDA is linked to cancer.