IRF4 and diffuse large B-cell lymphoma: Regarding AID-related mutations, in DLBCL most commonly affected chromosomes involved the presence of either immunoglobulin related genes: IGH (chr14), IGL (chr22), IGK (chr2), or genes already related with off-target AID activity: PIM1, IRF4, HIST1H1C (chr6; Supplementary Fig. 4)24.