MDM2 and cancer: On their own, MDM2 inhibitors (e.g., nutlin, idasanutlin, siremadlin/HDM201, milademetan) and the PPM1D inhibitor GSK2830371 show limited effects on cell viability, but dual inhibition of the p53 repressors provokes an apoptotic response in cancer cell types of diverse origin29,31,32,69.