On their own, MDM2 inhibitors (e.g., nutlin, idasanutlin, siremadlin/HDM201, milademetan) and the PPM1D inhibitor GSK2830371 show limited effects on cell viability, but dual inhibition of the p53 repressors provokes an apoptotic response in cancer cell types of diverse origin29,31,32,69. The gene discussed is PPM1D; the disease is cancer.