C/EBPβ play an important role in ADORA2A expression in macrophage [26, 27], we found C/EBPβ was a transcription factor for Adora2a, C/ebpβ and Adora2a were both regulated by JMJD3-induced H3K27me3 demethylation in LPS-induced ALI. This evidence concerns the gene KDM6B and acute respiratory distress syndrome.