NPC1 and nasopharyngeal carcinoma: The Npc1nih (hereafter referred to as Npc1−/−) mouse arose from a spontaneous insertional mutation resulting in undetectable levels of NPC1 protein13 and recapitulates many of the neuropathological hallmarks observed in infantile onset NPC, including hypomyelination14, 15, 16, 17 and cerebellar degeneration.18