Taken together, these findings suggest that HSP amplification in Npc1−/− mice improves cerebellar myelination and rescues cerebellar atrophy by normalising the population of mature OLs required for proper myelin formation, potentially through a Fyn kinase-mediated mechanism though further work is needed to confirm that saracatinib blocked myelination through inhibition of Fyn phosphorylation. This evidence concerns the gene HSP90B2P and Cerebellar atrophy.