Together, we propose a novel viral strategy whereby the viral protein CrPV-1A targets Nup358 for degradation via its R146-containing C-terminal tail and recruitment of the Cul2-Rbx1-EloBC complex inhibiting SG formation and RNA transport, consequently leading to poly (A)+ mRNA in the nucleus that further contributes to SG inhibition and facilitate productive virus infection. This evidence concerns the gene CUL2 and viral infectious disease.