TS-Hyper probes were identified for the SDHB-RCC tumors in this cohort and the two external cohorts (Pheo/PGL and GIST) by selecting probes with β-values of ≤0.2 in all normal tissue associated with each cohort and an average tumor β-value ≥0.4 higher than the average normal tissue β-value. The gene discussed is SDHB; the disease is renal cell carcinoma.