To evaluate the general level of hypermethylation within each tumor all CpG island probes with β-values less than 0.2 in all 11 associated normal samples (4x HLRCC normal, 4x SDHB-RCC normal, and 3x VHL normal) were identified (n = 31287) (S6 Table). Here, SDHB is linked to renal cell carcinoma.