In the case of the HLRCC tumors, this CIMP phenotype has been seen within a previous study of 20 FH-deficient tumors, both with germline and sporadic FH mutations, and within the 10 CIMP-RCCs tumors identified within the Cancer Genome Atlas (TCGA) analysis of RCC [26, 33]. The gene discussed is FH; the disease is renal cell carcinoma.