The HLRCC tumors showed methylation-associated downregulation of SFRP1, FRZB (previously known as SFRP3), and WNT3 mRNA expression, all components of the WNT pathway, but no downregulation of DKK1 (S3 Fig in S1 File). The gene discussed is DKK1; the disease is hereditary leiomyomatosis and renal cell cancer.