SDHB and hereditary leiomyomatosis and renal cell cancer: HLRCC-specific probes were selected that had β-values >0.5 in at least 13 out of the 15 HLRCC tumors and <0.2 in all other tumor and normal samples, including SDHB-RCC tumors, and this identified exactly 25 CpG island probes (S5 Table).