A cohort of 34 tumor samples and 11 associated normal samples consisting of 15 HLRCC syndrome renal tumors from the 12 individual patients with 4 associated normal samples, 6 SDHB mutation-related renal tumors with 4 associated normal samples, 5 VHL syndrome renal tumors with 3 associated normal samples, 4 HPRC syndrome renal tumors and 4 BHD syndrome renal tumors was selected for evaluation with Illumina HumanMethylation450 BeadChip arrays (GSE126441). The gene discussed is SDHB; the disease is Birt-Hogg-Dubé syndrome.