Comparison of the data in these previous studies with the cohort herein demonstrated a stronger hypermethylation signature was seen in the GIST and pheochromocytoma/paraganglioma samples in comparison to the SDHB-RCC samples and that the pheochromocytoma/paraganglioma samples showed a variable degree of hypermethylation, like the SDHB-RCCs. This evidence concerns the gene SDHB and hereditary pheochromocytoma-paraganglioma.