OVOL1 was hypermethylated and downregulated in the HLRCC tumors and encodes a transcription factor that has been shown to suppress expression of MYC and ZEB1, a transcriptional promoter of epithelial-to-mesenchymal transition (EMT) [47–50]. The gene discussed is OVOL1; the disease is hereditary leiomyomatosis and renal cell cancer.