This identified 16 CIMP-specific probes that had β-values >0.5 in at least 18 out of the 21 HLRCC/SDHB-RCC tumors and 15 HLRCC-specific probes that had β-values >0.5 in at least 10 out of the 15 HLRCC tumors (S5 Table). Here, SDHB is linked to hereditary leiomyomatosis and renal cell cancer.