SNCA and multiple system atrophy: Notably, the perinuclear inclusions observed in the E46K PFF–inoculated TgM47+/- mice differ from the pathology observed in MSA-inoculated TgM83+/- mice, which is characterized by the presence of phosphorylated α-synuclein throughout the neuronal cell body and neurites in the hindbrain (Fig 3B).