AKR1B1 and cancer: In addition, we analyzed the expression of these 4 genes in breast cancer tissues using data from Cancer Genome Atlas (TCGA) and draw box plots using GEPIA (http://gepia.cancer-pku.cn/index.html) [25], which showed that RASGRF2, AKR1B1 and CRMP1 were low expressed in breast Cancer tissues, while RHOF was high expressed in breast Cancer tissues (Fig 2B).