Regarding KEGG enrichment-based PPI network analysis, MTA2 and AGO2 proteins were predicted as central mediators of multiple signaling pathways including apoptosis, miRNAs in cancer, ubiquitin-mediated proteolysis, nucleosome remodeling and deacetylase (NuRD) complex, p53, mitogen-activated protein kinases (MAPKs) and FOXO signaling pathways (Fig 3C). This evidence concerns the gene WNK2 and cancer.