Similarly, levels of both podocin and WT-1 were significantly reduced (both P < 0.001) in PAN rats compared with control rats; they were also significantly reduced (podocin: P = 0.002 and WT-1: P < 0.001) in PAN + NICO rats (Fig. 2, G and N). The gene discussed is NPHS2; the disease is polyarteritis nodosa.