CCS and invasive breast carcinoma: Interestingly, the Progression Free Survival (PFI) plot for phosphorylated AKT [AKT_pS473, The Cancer Proteome Atlas (TCPA), using the TCGA breast invasive carcinoma cohort (BRCA)] and the Relapse Free Survival (RFS) plot for CCS mRNA (Kaplan Meier Plotter, KMPLOT database) [33], showed that the progression of the disease was significantly reduced in patients with higher levels of AKT activation (Fig. 8e) and with increased level of CCS (Fig. 8f), which, in turn implies a lower Cu content in those patients.