The relevance of our findings on the relation between Cu homeostasis and the activation of AKT in modulating TNBC aggressiveness was further corroborated by the analysis of the GENT2 DB, TCPA Pan-cancer (BRCA) and KMPLOT databases of the mRNA level of total AKT and CCS, pAKT-S473 in breast cancer patients. This evidence concerns the gene CCS and cancer.