CCS and breast neoplasm: Intriguingly, we found that TNBC patients show lower levels of both total AKT and CCS than patients affected by other tumor subtypes.We found the same expression profile also in the claudin-low breast tumors, aggressive subtypes of highly heterogeneous malignancies characterized by the lack of HER2, the low expression of cell–cell adhesion genes and high expression of EMT genes [59].