To summarize, activation of macrophages seemed to play a major role in anti-tumor activity of KD033 in hPDL1- tumors as shown in increased expression of genes involved in macrophage signaling, co-stimulation and pro-inflammatory cytokines/chemokines secretion in addition to some evidence of direct effect of KD033 on macrophages in vitro. Here, CD274 is linked to neoplasm.