We identified four novel DDH candidate genes occurring with variants in several different families, and we found very damaging variants in the following known candidate genes from human and canine hip dysplasia: DACH1, MYH10, NOTCH2, TBX4, EVC2, OTOG, and SHC3, which has important implications for the development of diagnostic methods for DDH. Here, SHC3 is linked to Hip dysplasia.