We and others previously found that Slc38a5 was drastically down-regulated in both Lrp5−/− and Ndpy/− retinas (Chen et al., 2012; Xia et al., 2010; Schäfer et al., 2009), experimental models of two genetic vascular eye diseases: familial exudative vitreoretinopathy (FEVR) and Norrie disease, respectively. The gene discussed is LRP5; the disease is exudative vitreoretinopathy.