PHGDH and endothelial dysfunction: For example, serine deprivation in the absence of a synthesizing enzyme phosphoglycerate dehydrogenase causes lethal vascular defects in mice (Vandekeere et al., 2018), whereas serine-glycine metabolism is also required in angiogenesis and linked to endothelial dysfunction in response to oxidized phospholipids (Hitzel et al., 2018).