Therefore, regulation and availability of signaling biomolecules (e.g., NO, and brain‐derived neurotrophic factor—BDNF) and regulation of signaling pathways (e.g., cAMP‐response element‐binding protein—CREB) are essential during health and illness, including the symptoms of migraine attacks, as stressful insults to the brain (González‐Rodríguez et al., 2019; Khosravi et al., 2019). The gene discussed is BDNF; the disease is migraine disorder.