BDNF and migraine disorder: That is, through regulation of local and cortical endothelium releasing factors (e.g., NO and BDNF), regular aerobic exercises, nasal breathing, and visual exercises facilitate and rearrange cortical and oscillatory feedback signaling between cranial motor nerves, brain stem, thalamus, hypothalamus, motor, and sensory cortices, all of which are closely related to a brain with migraine (Dinç et al., 2020; Dorner et al., 2003; Matteo et al., 2016; Ploughman et al., 2007; Savchenko et al., 1997; Sparks, 2002).