Consistent with our published data in the lungs of mice with Bleo-injury and lung tissue from individuals with IPF (Elliot et al., 2019; Rubio et al., 2018), Cav-1 protein decreased (Figure 7B,Figure 7—source data 1) and ERα protein expression increased (Figure 7C, Figure 7—source data 1) after U-IPFexo were injected into human lung punches. This evidence concerns the gene CAV1 and idiopathic pulmonary fibrosis.