WEE1 and legionellosis: For instance, during Legionella infection, several unique pathogen-encoded genes are involved in cytoskeletal rearrangement; for example, LegG1 promotes microtubule stabilization via activating Ran GTP, but LegK2, a protein kinase, inhibits actin polymerization on the Legionella-containing vacuole (27, 57, 58).