LIPA and infection: Moreover, several lipases (e.g., NCEH1 and LIPA) were increased in response to infection, suggesting that VACV might stimulate lipid uptake and storage, followed by lipolysis to generate FAs to fuel FAO, which would imply a different mechanism of ATP generation than that observed in BSC40 cells and HFFs, in which FAO was fueled by FAS (30).