NR4A1 and obesity due to melanocortin 4 receptor deficiency: Fat accumulation is lower in men and higher in women, due to essential body fat deposited in the mammary glands, and it can be further explained by differences in hormones, hormone receptors and enzyme concentrations.19,33 In many African countries, including South Africa, overweight and obesity are associated with a perception of ‘wealthy and healthy’, but this perception has drastically changed on the basis that overweight and obesity are associated with many noncommunicable diseases.34