SETD2 and neoplasm: Neutrophil diversity and plasticity underlie its dual potential in the TME.[4b] Therefore, the role of neutrophils in tumor progression has two sides, including antitumoral function via directly killing tumor cells and protumoral function by impairing T‐cell mediated cytotoxicity or enhancing metastasis through NETosis.[6, 7] Next, we asked whether Setd2 loss was able to reprogram neutrophils into protumoral function directly.