Previously, we reported that PI3K‐AKT signaling was boosted in Setd2KO pancreatic tumor cells.[8a] Here, in an orthotopic model, we further confirmed the high level of AKT phosphorylation in Setd2KO tumors compared with Setd2WT tumors (Figure 4H). This evidence concerns the gene AKT1 and pancreatic neoplasm.