As shown, the Setd2KO tumor burden on the pancreas was reduced in both a‐Ly6G and a‐PD‐1 treatment groups in Setd2WT and Setd2KO tumor‐bearing mice, accompanied by a marked increase in IFNγ production in CD8+ T cells (Figure 3K; Figure S5G, Supporting Information). This evidence concerns the gene CD8A and neoplasm.