BRCA1 and neoplasm: Western blot assays of tumor lysates demonstrated that DNA damage and apoptosis were induced only modestly by STELB or TMZ when administered alone but were significantly enhanced upon coadministration, as evidenced by significant decreases in BRCA1, BRCA2, and RAD51 levels and an increase in γ‐H2AX level and PARP cleavage (Figure 7F).