PTEN and cancer: While the N‐terminal signaling peptide carrying proteins are released through the ER‐Golgi canonical secretion route, proteins without that N‐terminal signaling peptide can be secreted via pathways including secretory autophagy.[29] Protein kinase VLK and phosphatase PTEN can be constitutively secreted via their N‐terminal signaling peptide guidance in cancer cells.[8, 9, 10] SIRT2 can be secreted from macrophages under stimulation.