We have evaluated the effect of extracellular SIRT2 on tumor microenvironmental editing using integrin (αvβ3) targeted Arg‐Gly‐Asp (RGD) peptide probe for cancer optical imaging.[48] The vWAF domain of Integrin extracellular domain can bind to the RGD motif of matrix proteins.[49] RGD peptide‐based probes have emerged as a promising approach for visualization, localization, and measurement of cancer cells in vivo. This evidence concerns the gene SIRT2 and cancer.