THBS1 and open-angle glaucoma: Interestingly, a recent analysis of WES data from the UK Biobank (43) identified a nominally significant gene-based association (P = 0.01, sequence kernel association test [SKAT]) for THBS1 rare coding variants and POAG (ICD-10 diagnosis code H40), suggesting that further study of rare THBS1-coding variants in adult-onset POAG might be of interest.