EFEMP1 and juvenile open angle glaucoma: Most of the genes responsible for childhood glaucoma (CYP1B1, LTBP2, PITX2, PAX6, FOXC1, TEK, ANGPT1, CPAMD8) cause abnormal ocular development (8–11), whereas 2 genes, MYOC and EFEMP1, are ECM proteins with mutations causing intracellular aggregation in TM cells (12, 13).