Protein-coding variants affecting various members of the ADAMTS family (a disintegrin and metalloproteinase with THBS1 motifs) have been associated with a range of glaucoma-related phenotypes in dogs (31, 32), however, in humans ADAMTS mutations cause syndromic developmental disorders not directly related to glaucoma, including Weill Marchesani syndrome, a systematic disease causing small lenses, short stature, and joint abnormalities (33). This evidence concerns the gene THBS1 and Weill-Marchesani syndrome.