PINK1 and subarachnoid hemorrhage: Therefore, several studies reported that the treatment of cerebral I/R using chemicals could increase Nrf2 expression up-regulated PINK1, Parkin, Beclin1 and LC3II/I, and these results indicated that Nrf2 may ameliorate cell injury by promoting PINK1 and subsequent mitophagy in cerebral I/R [44] and subarachnoid hemorrhage [45].