Based on the role of Nrf2 to alleviate oxidative stress and its protective effect in CNS, the use of Nrf2 agonists or treatments to induce endogenous Nrf2 may also play a therapeutic effect in some neurodegenerative diseases with oxidative stress as one of the pathological causes, such as Parkinson's disease or Alzheimer's disease [144, 145]. Here, NFE2L2 is linked to Alzheimer disease.