NFE2L2 and brain ischemia: An animal experiment also confirmed that resveratrol treatment induced a protective effect after cerebral ischemia through activating Nrf2, while this protection was weakened in Nrf2-/- group, along with decreased concentrations of antioxidant proteins thioredoxin (Trx) and NQO1 and enhanced reactive oxygen species (ROS) contents in their astrocytes [9].