As the CXCL13 is observed as the constituent member of the well‐described chemokine gene signature associated with TLS formation17, 23, 24, 25 and also well associated with the favorable outcome in pan‐cancer analysis,26 we hypothesized that the investigating the transcriptional upregulation of CXCL13, consider it as a surrogated marker of TLS, could have a correlation with favorable predictive value in the response of lung adenocarcinoma to ICIs and known genes related to the ICI response. The gene discussed is CXCL13; the disease is cancer.