The results showed the suppression of hsa‐circ‐0052001 downregulated p‐ERK, p‐P38, and p‐JNK, while there was no significant change in ERK, P38, and JNK, further confirming that hsa‐circ‐0052001 could promote the proliferative and invasion of GC cells via the MAPK pathway. This evidence concerns the gene MAPK8 and gastric cancer.