Pathological gene variants and altered expression level of the translational machinery including initiation factors, elongation factors, ribosomal subunits and tRNA synthetase genes have been implicated in many other neurological disorders (for review, see Skariah and Todd, 2021), but precisely how disruption of ribosomes contributes to neurodegeneration in CLN3 disease is not yet known. The gene discussed is CLN3; the disease is nervous system disorder.