KMT2A and acute myeloid leukemia: Of note, Liu et al also found that IMPDH inhibition induced the activation of the p53‐p21 pathway and downregulation of the CD98/Lat1‐mTORC1 pathway, both of which have been shown to be effective in suppressing the development of MLL‐rearranged AML (Bajaj et al, 2016; Hayashi et al, 2019).