CDKN2A and malignant pleural mesothelioma: Malignant pleural mesotheliomas are mostly characterized by frequent deletions (50–80%) of the CDKN2A/B locus (encoding the CDK4/6 inhibitors p16INK4A and p15INK4B) [8, 12, 13, 14], which are associated with shorter overall survival [15].