Nevertheless, a number of more recent preclinical studies also suggested that the simultaneous combination of chemotherapy and CDK4/6 inhibition can have cooperative antitumour effects, in part because CDK4/6 inhibition also reduces the E2F‐dependent expression of multiple genes required for DNA damage repair and thus would limit the ability of tumour cells to recover from chemotherapy‐mediated damage [27, 28]. The gene discussed is CDK4; the disease is neoplasm.