To demonstrate the cellular function of RyR2, we first knocked down RyR2 expression using two independent shRNA sequences in KRAS mutant CRC cell line DLD‐1 (KRASG13V), SW480 (KRASG12V) and HCT116 (KRASG13D) (Fig. 2A; Fig. S1B). Here, RYR2 is linked to colorectal carcinoma.