To demonstrate the cellular function of RyR2, we first knocked down RyR2 expression using two independent shRNA sequences in KRAS mutant CRC cell line DLD‐1 (KRASG13V), SW480 (KRASG12V) and HCT116 (KRASG13D) (Fig. 2A; Fig. S1B). The gene discussed is KRAS; the disease is colorectal carcinoma.