CD8A and infection: In LCMV (docile strain) infection, higher viral titers have been reported in TFH cells in mice receiving CXCR5-deficient virus-specific CD8+ T cells than in mice receiving CXCR5-sufficient virus-specific CD8+ T cells, but with no difference in non-TFH cell infections, suggesting that TFC cells play a specific role in controlling TFH infection (He et al., 2016; Im et al., 2016).