Moreover, hypoxia was demonstrated to facilitate breast carcinoma invasion by inhibiting glycogen synthase kinase 3β (GSK-3β) activity, increasing microtubule stability, and regulating the microtubule-dependent trafficking of Rab11-containing vesicles, and finally Rab11 targeted to the integrin α6β4 to promote carcinoma cells migration (28). This evidence concerns the gene RAB11A and breast carcinoma.