In esophageal squamous cell carcinoma (ESCC), LINC00514 promotes ESCC cell proliferation and invasion through the absorption of miR-378a-5p by sponges as competitive endogenous RNA, leading to the upregulation of adipoformation-related proteins, including acetyl-coenzyme (Co)A carboxylase α, SPHK1, FAS, and stearoyl-CoA desaturase 1 (55). The gene discussed is SPHK1; the disease is esophageal squamous cell carcinoma.