We also observed that high SPARC and WNT3A expressions in the tumor stroma had a significant influence on OS (HR 0.55 for higher versus low expression, CI 0.30-1.00, P=0.050; HR 0.54 for higher versus lower expression, CI 0.30–0.99, P=0.046; respectively). The gene discussed is WNT3A; the disease is neoplasm.