Combined analysis using the databases of CCLE, GEPIA, cBioPortal, STRING, and GeneMANIA databases manifested high-expressed FZD6 in AML cell lines and patients, which was positively correlated with the risk factors, OS and HSCT, and that 4 gene sets (MYC targets, HEME metabolism, E2F targets, and UV response) were differentially enriched in the high FZD6 expression group. Here, FZD6 is linked to acute myeloid leukemia.