The findings revealed that its action on AR, MIF, HSP90B1, and MAOA genes regulated several biological processes and related signaling pathways to interfere with the occurrence and development of PCa while its action on APOE, CA2, IGFBP3, MIF, F10, and NR3C1 genes was also important in interfering with clinical prognostic regression. Here, IGFBP3 is linked to posterior cortical atrophy.