EDN1 and cardiac hypertrophy: Compared with the Zn50 group, in the intestine of pigs in the Zn100 group, the top three down-regulated pathways were endothelin-1 signalling, relaxin signalling and the role of nuclear factor of activated T-cells (NFAT) in cardiac hypertrophy pathway, while the up-regulated pathways included PI3K signalling in B lymphocytes, leukocyte extravasation signalling and Th2 pathway (Supplementary Fig. S1; https://doi.org/10.6084/m9.figshare.15079074).